Enhancement of hepatitis B virus replication by its X protein in transgenic mice.

doi:10.1128/jvi.76.5.2579-2584.2002

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Article

Enhancement of hepatitis B virus replication by its X protein in transgenic mice.

Journal of virology - 1 Mar 2002

Xu Zhenming, Yen T S Benedict, Wu Lanying, Madden Charles R, Tan Wenjie, Slagle Betty L, Ou Jing-hsiung

Abstract excerpt

Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV...

Topics

Animals
Gene Expression Regulation, Viral
Hepatitis B
Hepatitis B virus
Mice
Mice, Transgenic
Mutation
Trans-Activators
Transcriptional Activation
Viral Regulatory and Accessory Proteins
Virus Replication

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