Article
Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites.
Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008
Mustonen Ville, Kinney Justin, Callan Curtis G, Lässig Michael
Abstract excerpt
We present a genomewide cross-species analysis of regulation for broad-acting transcription factors in yeast. Our model for binding site evolution is founded on biophysics: the binding energy between transcription factor and site is a quantitative phenotype of regulatory function, and selection i...
Topics
- Binding Sites
- Epistasis, Genetic
- Evolution, Molecular
- Fungal Proteins
- Genome, Fungal
- Models, Genetic
- Mutation
- Quantitative Trait, Heritable
- Saccharomyces
- Selection, Genetic
- Stochastic Processes
- Thermodynamics
- Transcription Factors