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Article

Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Mustonen Ville, Kinney Justin, Callan Curtis G, Lässig Michael

Abstract excerpt

We present a genomewide cross-species analysis of regulation for broad-acting transcription factors in yeast. Our model for binding site evolution is founded on biophysics: the binding energy between transcription factor and site is a quantitative phenotype of regulatory function, and selection is given by a fitness landscape that depends on this phenotype. The model quantifies conservation, as well as loss and...

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Identifiers

PMID: 18723669
DOI: 10.1073/pnas.0805909105
PMCID: PMC2527919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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