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Article

Evolutionary origins of transcription factor binding site clusters.

Molecular biology and evolution - 1 Mar 2012

He Xin, Duque Thyago S P C, Sinha Saurabh

Abstract excerpt

Empirical studies have revealed that regulatory DNA sequences such as enhancers or promoters often harbor multiple binding sites for the same transcription factor. Such "homotypic site clustering" has been hypothesized as arising out of functional requirements of the sequences. Here, we propose an alternative explanation of this phenomenon that multisite enhancers are common because they are favored by...

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Identifiers

PMID: 22075113
DOI: 10.1093/molbev/msr277
PMCID: PMC3278477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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