Article
The evolution, evolvability and engineering of gene regulatory DNA.
Nature - 1 Mar 2022
Vaishnav Eeshit Dhaval, de Boer Carl G, Molinet Jennifer, Yassour Moran, Fan Lin, Adiconis Xian, Thompson Dawn A, Levin Joshua Z, Cubillos Francisco A, Regev Aviv
Abstract excerpt
Mutations in non-coding regulatory DNA sequences can alter gene expression, organismal phenotype and fitness1-3. Constructing complete fitness landscapes, in which DNA sequences are mapped to fitness, is a long-standing goal in biology, but has remained elusive because it is challenging to generalize reliably to vast sequence spaces4-6. Here we build sequence-to-expression models that capture fitness landscapes...
Topics
- Biological Evolution
- DNA
- Evolution, Molecular
- Gene Expression Regulation
- Genetic Drift
- Models, Genetic
- Mutation
- Phenotype
- Saccharomyces cerevisiae