Article

The Energetics of Molecular Adaptation in Transcriptional Regulation

2019-05-15

Abstract excerpt

Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains difficult to link sequence-level perturbations to systems-level responses. Here, we present a framework centered on measuring changes in the free energy of the system to link individual mutations in an allosteric transcriptional repressor to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9b2da99-c112-505d-987e-07c879590091
DOI: 10.1101/638270

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Energetics of Molecular Adaptation in Transcriptional RegulationDOI 10.1101/638270Read

The genotype-phenotype landscape of an allosteric protein.Semantic proximity Read

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read

Reliable prediction of complex phenotypes from a modular design in free energy space: an extensive exploration of the lac operon.Semantic proximity Read

The genotype-phenotype landscape of an allosteric proteinSemantic proximity Read

On the mechanistic nature of epistasis in a canonical cis-regulatory element.Semantic proximity Read

Tradeoffs and optimality in the evolution of gene regulation.Semantic proximity Read

Epistasis shapes the fitness landscape of an allosteric specificity switch.Semantic proximity Read

Changes in gene expression shift and switch genetic interactionsSemantic proximity Read

A parameterized two-domain thermodynamic model explains diverse mutational effects on protein allostery.Semantic proximity Read

Multiple peaks and reciprocal sign epistasis in an empirically determined genotype-phenotype landscape.Semantic proximity Read

Energy-dependent fitness: a quantitative model for the evolution of yeast transcription factor binding sites.Semantic proximity Read