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Article

Changes in selective effects over time facilitate turnover of enhancer sequences.

Genetics - 1 Feb 2011

Bullaughey Kevin

Abstract excerpt

Correct gene expression is often critical and consequently stabilizing selection on expression is widespread. Yet few genes possess highly conserved regulatory DNA, and for the few enhancers that have been carefully characterized, substantial functional reorganization has often occurred. Given that natural selection removes mutations of even very small deleterious effect, how can transcription factor binding...

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Identifiers

PMID: 21098721
DOI: 10.1534/genetics.110.121590
PMCID: PMC3030497

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Source receipt: pubmed, retrieved 7 Sept 2026.

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