Article
Evolution and selection in yeast promoters: analyzing the combined effect of diverse transcription factor binding sites.
PLoS computational biology - 1 Jan 2008
Raijman Daniela, Shamir Ron, Tanay Amos
Abstract excerpt
In comparative genomics one analyzes jointly evolutionarily related species in order to identify conserved and diverged sequences and to infer their function. While such studies enabled the detection of conserved sequences in large genomes, the evolutionary dynamics of regulatory regions as a whole remain poorly understood. Here we present a probabilistic model for the evolution of promoter regions in yeast,...
Topics
- Base Sequence
- Binding Sites
- Computer Simulation
- Evolution, Molecular
- Genetic Variation
- Genome, Fungal
- Models, Genetic
- Molecular Sequence Data
- Promoter Regions, Genetic
- Protein Binding
- Saccharomyces cerevisiae