Article
From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation.
Trends in genetics : TIG - 1 Mar 2009
Mustonen Ville, Lässig Michael
Abstract excerpt
Evolution is a quest for innovation. Organisms adapt to changing natural selection by evolving new phenotypes. Can we read this dynamics in their genomes? Not every mutation under positive selection responds to a change in selection: beneficial changes also occur at evolutionary equilibrium, repairing previous deleterious changes and restoring existing functions. Adaptation, by contrast, is viewed here as a...
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