Frequent gain and loss of functional transcription factor binding sites.

doi:10.1371/journal.pcbi.0030099

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Article

Frequent gain and loss of functional transcription factor binding sites.

PLoS computational biology - 1 May 2007

Doniger Scott W, Fay Justin C

Abstract excerpt

Cis-regulatory sequences are not always conserved across species. Divergence within cis-regulatory sequences may result from the evolution of species-specific patterns of gene expression or the flexible nature of the cis-regulatory code. The identification of functional divergence in cis-regulatory sequences is therefore important for both understanding the role of gene regulation in evolution and annotating...

Topics

Base Sequence
Binding Sites
Evolution, Molecular
Gene Frequency
Genetic Variation
Molecular Sequence Data
Protein Binding
Regulatory Sequences, Nucleic Acid
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Analysis, DNA
Transcription Factors

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Identifiers

PMID: 17530920
DOI: 10.1371/journal.pcbi.0030099
PMCID: PMC1876492

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