Article

Approximation to the distribution of fitness effects across functional categories in human segregating polymorphisms

2014-02-04

Abstract excerpt

Quantifying the proportion of polymorphic mutations that are deleterious or neutral is of fundamental importance to our understanding of evolution, disease genetics and the maintenance of variation genome-wide. Here, we develop an approximation to the distribution of fitness effects (DFE) of segregating single-nucleotide mutations in humans. Unlike previous methods, we do not assume that synonymous mutations are n...

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Literature Corpus work: be4b1a71-e8c9-59fc-a88c-999b93326a61
DOI: 10.1101/002345

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