Article
Position specific variation in the rate of evolution in transcription factor binding sites.
BMC evolutionary biology - 28 Aug 2003
Moses Alan M, Chiang Derek Y, Kellis Manolis, Lander Eric S, Eisen Michael B
Abstract excerpt
BACKGROUND: The binding sites of sequence specific transcription factors are an important and relatively well-understood class of functional non-coding DNAs. Although a wide variety of experimental and computational methods have been developed to characterize transcription factor binding sites, they remain difficult to identify. Comparison of non-coding DNA from related species has shown considerable promise in...
Topics
- Artifacts
- Base Composition
- Base Sequence
- Binding Sites
- Computational Biology
- Conserved Sequence
- Evolution, Molecular
- Gene Expression Regulation, Fungal
- Genetic Variation
- Genome, Fungal
- Mutagenesis
- Predictive Value of Tests
- Promoter Regions, Genetic
- Saccharomyces