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Article

Position specific variation in the rate of evolution in transcription factor binding sites.

BMC evolutionary biology - 28 Aug 2003

Moses Alan M, Chiang Derek Y, Kellis Manolis, Lander Eric S, Eisen Michael B

Abstract excerpt

BACKGROUND: The binding sites of sequence specific transcription factors are an important and relatively well-understood class of functional non-coding DNAs. Although a wide variety of experimental and computational methods have been developed to characterize transcription factor binding sites, they remain difficult to identify. Comparison of non-coding DNA from related species has shown considerable promise in...

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PMID: 12946282
DOI: 10.1186/1471-2148-3-19
PMCID: PMC212491

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