Article
A molecular bar-coded DNA repair resource for pooled toxicogenomic screens.
DNA repair - 1 Nov 2008
Rooney John P, Patil Ashish, Zappala Maria R, Conklin Douglas S, Cunningham Richard P, Begley Thomas J
Abstract excerpt
DNA damage from exogenous and endogenous sources can promote mutations and cell death. Fortunately, cells contain DNA repair and damage signaling pathways to reduce the mutagenic and cytotoxic effects of DNA damage. The identification of specific DNA repair proteins and the coordination of DNA repair pathways after damage has been a central theme to the field of genetic toxicology and we have developed a tool for...
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