Article
Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers.
Nature methods - 1 Aug 2008
Yan Zhun, Costanzo Michael, Heisler Lawrence E, Paw Jadine, Kaper Fiona, Andrews Brenda J, Boone Charles, Giaever Guri, Nislow Corey
Abstract excerpt
The ability to perform complex bioassays in parallel enables experiments that are otherwise impossible because of throughput and cost constraints. For example, highly parallel chemical-genetic screens using pooled collections of thousands of defined Saccharomyces cerevisiae gene deletion strains are feasible because each strain is bar-coded with unique DNA sequences. It is, however, time-consuming and expensive...
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