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Article

Regulation of Chk1 by its C-terminal domain.

Molecular biology of the cell - 1 Nov 2008

Kosoy Ana, O'Connell Matthew J

Abstract excerpt

Chk1 is a protein kinase that is the effector molecule in the G2 DNA damage checkpoint. Chk1 homologues have an N-terminal kinase domain, and a C-terminal domain of approximately 200 amino acids that contains activating phosphorylation sites for the ATM/R kinases, though the mechanism of activation remains unknown. Structural studies of the human Chk1 kinase domain show an open conformation; the activity of the...

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Identifiers

PMID: 18716058
DOI: 10.1091/mbc.e08-04-0444
PMCID: PMC2575178

Genes

ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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