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Article

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.

Current genetics - 1 Jan 2001

Wan S, Walworth N C

Abstract excerpt

The protein kinase Chk1 is required in the fission yeast Schizosaccharomyces pombe for delaying cell cycle progression in response to DNA damage. Chk1 becomes phosphorylated when DNA is damaged by a variety of agents, including the anti-tumor drug camptothecin. To further characterize the behavior of Chk1 in response to DNA damage, we used PCR-based mutagenesis of the chk1 gene coupled with in vivo gap repair to...

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Identifiers

PMID: 11270571
DOI: 10.1007/s002940000172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.PMID 11270571Read ↗

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