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Article

A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.

Current genetics - 1 Jan 2001

Wan S, Walworth N C

Abstract excerpt

The protein kinase Chk1 is required in the fission yeast Schizosaccharomyces pombe for delaying cell cycle progression in response to DNA damage. Chk1 becomes phosphorylated when DNA is damaged by a variety of agents, including the anti-tumor drug camptothecin. To further characterize the behavio...

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Identifiers

PMID: 11270571
DOI: 10.1007/s002940000172

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11270571-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A novel genetic screen identifies checkpoint-defective alleles of Schizosaccharomyces pombe chk1.PMID 11270571Read ↗

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A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1Semantic proximity Read ↗

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.Semantic proximity Read ↗

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.Semantic proximity Read ↗

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p56(chk1) protein kinase is required for the DNA replication checkpoint at 37 degrees C in fission yeast.Semantic proximity Read ↗

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