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Article

Specific role of Chk1 phosphorylations in cell survival and checkpoint activation.

Molecular and cellular biology - 1 Apr 2007

Niida Hiroyuki, Katsuno Yuko, Banerjee Birendranath, Hande M Prakash, Nakanishi Makoto

Abstract excerpt

Chk1 is a multifunctional protein kinase that plays essential roles in cell survival and cell cycle checkpoints. Chk1 is phosphorylated at multiple sites by several protein kinases, but the precise effects of these phosphorylations are largely unknown. Using a knockout-knockin system, we examined the abilities of Chk1 mutants to reverse the defects of Chk1-null cells. Wild-type Chk1 could rescue all the defects...

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Identifiers

PMID: 17242188
DOI: 10.1128/MCB.01611-06
PMCID: PMC1899884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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