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Article

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

10 Jan 2012

Abstract excerpt

Mdc1 is a large modular phosphoprotein scaffold that maintains signaling and repair complexes at double-stranded DNA break sites. Mdc1 is anchored to damaged chromatin through interaction of its C-terminal BRCT-repeat domain with the tail of γH2AX following DNA damage, but the role of the N-terminal forkhead-associated (FHA) domain remains unclear. We show that a major binding target of the Mdc1 FHA domain is a...

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PMID: 22234878
DOI: 10.1093/nar/gkr1300

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