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Reality CHEK: Understanding the biology and clinical potential of CHK1

28 Sept 2020

Abstract excerpt

The DNA damage response enables cells to cope with various stresses that threaten genomic integrity. A critical component of this response is the serine/threonine kinase CHK1 which is encoded by the CHEK1 gene. Originally identified as a regulator of the G2/M checkpoint, CHK1 has since been shown to play important roles in DNA replication, mitotic progression, DNA repair, and overall cell cycle regulation....

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PMID: 32991949
DOI: 10.1016/j.canlet.2020.09.016

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