A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

Abstract excerpt

BACKGROUND: The cell-cycle checkpoint kinase Chk1 is essential in mammalian cells due to its roles in controlling processes such as DNA replication, mitosis and DNA-damage responses. Despite its paramount importance, how Chk1 controls these functions remains unclear, mainly because very few Chk1 substrates have hitherto been identified. RESULTS: Here, we combine a chemical genetics approach with high-resolution...

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