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Article

Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation.

Molecular biology of the cell - 1 Apr 2004

Katsuragi Yoshinori, Sagata Noriyuki

Abstract excerpt

The checkpoint kinase Chk1 undergoes ATR-mediated phosphorylation and activation in response to unreplicated DNA, but the precise mechanism of Chk1 activation is not known. In this study, we have analyzed the domain structure of Xenopus Chk1 and explored the mechanism of its activation by ATR-mediated phosphorylation. We show that the C-terminal region of Xenopus Chk1 contains an autoinhibitory region (AIR),...

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Identifiers

PMID: 14767054
DOI: 10.1091/mbc.e03-12-0874
PMCID: PMC379266

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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