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Article

Importance of a C-terminal conserved region of Chk1 for checkpoint function.

PloS one - 9 Jan 2008

Palermo Carmela, Hope Justin C, Freyer Greg A, Rao Hui, Walworth Nancy C

Abstract excerpt

BACKGROUND: The protein kinase Chk1 is an essential component of the DNA damage checkpoint pathway. Chk1 is phosphorylated and activated in the fission yeast Schizosaccharomyces pombe when cells are exposed to agents that damage DNA. Phosphorylation, kinase activation, and nuclear accumulation are events critical to the ability of Chk1 to induce a transient delay in cell cycle progression. The catalytic domain of...

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Camptothecin
Checkpoint Kinase 1
DNA, Fungal
Protein Kinases
Schizosaccharomyces

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces pombe Proteins

Substrate Specificity

Ultraviolet Rays

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Identifiers

PMID: 18183307
DOI: 10.1371/journal.pone.0001427
PMCID: PMC2173936

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Importance of a C-terminal conserved region of Chk1 for checkpoint function.PMID 18183307Read ↗

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