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Article

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

Genes & development - 15 Jun 2000

Liu Q, Guntuku S, Cui X S, Matsuoka S, Cortez D, Tamai K, Luo G, Carattini-Rivera S, DeMayo F, Bradley A, Donehower L A, Elledge S J

Abstract excerpt

Chk1, an evolutionarily conserved protein kinase, has been implicated in cell cycle checkpoint control in lower eukaryotes. By gene disruption, we show that CHK1 deficiency results in a severe proliferation defect and death in embryonic stem (ES) cells, and peri-implantation embryonic lethality in mice. Through analysis of a conditional CHK1-deficient cell line, we demonstrate that ES cells lacking Chk1 have a...

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Identifiers

PMID: 10859164
PMCID: PMC316686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.PMID 10859164Read ↗

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