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Article

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage.

Scientific reports - 3 Jun 2015

Gong Eun-Yeung, Smits Veronique A J, Fumagallo Felipe, Piscitello Desiree, Morrice Nick, Freire Raimundo, Gillespie David A

Abstract excerpt

The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates a high probability that this region of Chk1 contains a kinase-associated 1 (KA1) domain, a small, compact protein fold found in multiple protein kinases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26039276
DOI: 10.1038/srep10856
PMCID: PMC4454167

Genes

ATR
MARK3
SOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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