Article
Coupling cellular localization and function of checkpoint kinase 1 (Chk1) in checkpoints and cell viability.
The Journal of biological chemistry - 20 Jul 2012
Wang Jingna, Han Xiangzi, Feng Xiujing, Wang Zhenghe, Zhang Youwei
Abstract excerpt
Chk1 plays a key role in regulating the replication checkpoint and DNA damage response. Recent evidence suggests that mammalian Chk1 regulates both the nuclear and cytoplasmic checkpoint events. However, mechanisms regulating cellular mobilization of Chk1 were not well understood. Here, we report the identification of regions of human Chk1 that regulate its protein cellular localization and checkpoint function....
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