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Article

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2026

Oh Jang-Hyun, Hyun Ju-Yeon, Chen Shun-Jia, Varshavsky Alexander

Abstract excerpt

The Arg/N-degron pathway of Saccharomyces cerevisiae is mediated by two interacting E3 ubiquitin ligases, Ubr1 and Ufd4. We show here that the mitotic checkpoint kinase Chk1 bears a C-degron that can be recognized by both Ubr1 and Ufd4. Ubr1 is an E3 that can target both N-degrons and C-degrons. Deleting 4 residues from the C terminus of full-length Chk11-527 abrogates the bulk of Ubr1/Ufd4 affinity for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41945440
DOI: 10.1073/pnas.2605594123
PMCID: PMC13079399

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