Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome-Wide Assessment of Human Brain and Lymphocyte Senescence

19 Aug 2008

Abstract excerpt

BACKGROUND: Identifying biological pathways that vary across the age spectrum can provide insight into fundamental mechanisms that impact disease and frailty in the elderly. Few methodological approaches offer the means to explore this question on as broad a scale as gene expression profiling. Here, we have evaluated mRNA expression profiles as a function of age in two populations; one consisting of 191...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18714388
DOI: 10.1371/journal.pone.0003024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-Wide Assessment of Human Brain and Lymphocyte SenescencePMID 18714388Read ↗

The variability of expression of many genes and most functional pathways is observed to increase with age in brain transcriptome dataSemantic proximity Read ↗

Tissue-specific impacts of aging and genetics on gene expression patterns in humansSemantic proximity Read ↗

Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regionsSemantic proximity Read ↗

Pan-tissue Transcriptome Analysis Reveals Sex-dimorphic Human AgingSemantic proximity Read ↗

Genetic dysregulation of gene expression and splicing during a ten-year period of human agingSemantic proximity Read ↗

Single-cell transcriptomic and genomic changes in the aging human brainSemantic proximity Read ↗

Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological agingSemantic proximity Read ↗

Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissuesSemantic proximity Read ↗

Ageing Transcriptome Meta-Analysis Reveals Similarities Between Key Mammalian TissuesSemantic proximity Read ↗

Genetic interplay between human longevity and metabolic pathways - a large-scale eQTL study.Semantic proximity Read ↗

Transcriptomic changes highly similar to Alzheimer’s disease are observed in a subpopulation of individuals during normal brain agingSemantic proximity Read ↗

A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.