Article

The variability of expression of many genes and most functional pathways is observed to increase with age in brain transcriptome data

2019-01-22

Abstract excerpt

Ageing is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous studies and evolutionary theories of ageing suggest that ageing is not a programmed process but reflects dynamic stochastic events. In this study, we test whether transcriptional noise shows an increase with age, which would be expected from stochastic theories. Using human brain t...

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Literature Corpus work: ad1c8b8b-d3ef-56c4-a45a-370f15ba662b
DOI: 10.1101/526491

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