Article

Ageing Transcriptome Meta-Analysis Reveals Similarities Between Key Mammalian Tissues

2019-10-30

Abstract excerpt

1 Understanding the expression changes that come with age is an important step in understanding the ageing process as a whole. By combining such transcriptomic data with other sources of information, for instance protein-protein interaction (PPI) data, it is possible to make inferences about the functional changes that occur with age. To address this, we conducted a meta-analysis on 127 publicly available microarr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8acdda55-1d69-5a8a-b67c-b469ec9c5ca7
DOI: 10.1101/815381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ageing Transcriptome Meta-Analysis Reveals Similarities Between Key Mammalian TissuesDOI 10.1101/815381Read

Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissuesSemantic proximity Read

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.Semantic proximity Read

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderlySemantic proximity Read

The combination of differential expression and differential network connectivity analyses identifies RNA splicing and processing as common pathways altered with age across human tissuesSemantic proximity Read

Mutation accumulation differentially impacts ageing in mammalian tissuesSemantic proximity Read

Discovering Molecular Regulators of Ageing Using Mixture Models With RNA-sequencing DataSemantic proximity Read

Aging is associated with a systemic length-driven transcriptome imbalanceSemantic proximity Read

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationSemantic proximity Read

Inter-tissue convergence of gene expression during ageing suggests age-related loss of tissue and cellular identitySemantic proximity Read

Computational studies on ageing and age-related diseasesSemantic proximity Read

Conserved aging-related signatures of senescence and inflammation in different tissues and speciesSemantic proximity Read

Transcriptome features of striated muscle aging and predictability of protein level changesSemantic proximity Read