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Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

21 May 2021

Abstract excerpt

Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more...

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Share to Genetics, Aging, and Longevity in Model Organisms
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Share to Telomeres, Telomerase, and Senescence

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PMID: 34018656
DOI: 10.1111/acel.13357

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