Article

Transcriptomic changes highly similar to Alzheimer’s disease are observed in a subpopulation of individuals during normal brain aging

2021-06-02

Abstract excerpt

Aging is a major risk factor for late-onset Alzheimer’s disease (LOAD). How aging contributes to the development of LOAD remains elusive. In this study, we examined multiple large-scale transcriptomic data from both normal aging and LOAD brains to understand the molecular interconnection between aging and LOAD. We found that shared gene expression changes between aging and LOAD are mostly seen in the hippocampal a...

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Literature Corpus work: 4e4a2600-ff7a-5195-a773-cc68106b8250
DOI: 10.1101/2021.06.01.446628

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