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Article

Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.

Behavioural pharmacology - 1 Sept 2008

Perona Maria T G, Waters Shonna, Hall Frank Scott, Sora Ichiro, Lesch Klaus-Peter, Murphy Dennis L, Caron Marc, Uhl George R

Abstract excerpt

Antidepressant drugs produce therapeutic actions and many of their side effects via blockade of the plasma membrane transporters for serotonin (SERT/SLC6A2), norepinephrine (NET/SLC6A1), and dopamine (DAT/SLC6A3). Many antidepressants block several of these transporters; some are more selective. Mouse gene knockouts of these transporters provide interesting models for possible effects of chronic antidepressant...

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Identifiers

PMID: 18690111
DOI: 10.1097/FBP.0b013e32830cd80f
PMCID: PMC2644662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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