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Article

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour.

Journal of psychiatry & neuroscience : JPN - 1 Apr 2016

Isingrini Elsa, Perret Lea, Rainer Quentin, Sagueby Sara, Moquin Luc, Gratton Alain, Giros Bruno

Abstract excerpt

BACKGROUND: The monoaminergic transmitters dopamine (DA), noradrenaline (NE) and serotonin (5-HT) modulate cerebral functions via their extensive effects in the brain. Investigating their roles has led to the creation of vesicular monoaminergic transporter-2 (VMAT2) knockout (KO) mice. While this mutation results in postnatal death, VMAT2-heterozygous (HET) mice are viable and show a complex behavioural...

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Identifiers

PMID: 26505143
DOI: 10.1503/jpn.150028
PMCID: PMC4853208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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