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Article

Behavioural phenotyping of dopamine transporter knockdown mice using local small interference RNA.

Behavioural brain research - 25 Dec 2010

Chen Yao-Chu, Lai Wen-Sung

Abstract excerpt

The objective of this study was to evaluate basic behavioural phenotypes and methamphetamine-induced hyperactivity in dopamine transporter (DAT) knockdown and control mice after local injections of small interference RNA into ventral tegmental area/substantia nigra once every other day for 14 days. Local knockdown of DAT expression in the mouse brain did not affect basic behavioural functions, but these mice...

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Identifiers

PMID: 20558209
DOI: 10.1016/j.bbr.2010.06.008

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