Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.

Neuroscience - 19 Jun 2006

Zhao S, Edwards J, Carroll J, Wiedholz L, Millstein R A, Jaing C, Murphy D L, Lanthorn T H, Holmes A

Abstract excerpt

The 5-hydroxytryptamine transporter (5-HTT) regulates 5-hydroxytryptamine (5-HT) neurotransmission by removing 5-HT from the synaptic cleft. Emerging evidence from clinical and genetic studies implicates the 5-HTT in various neuropsychiatric conditions, including anxiety and depression. Here we report that a 5-HTT null mutant mouse line was generated by gene trapping that disrupted the sequence encoding the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Chemistry
Share to Citalopram

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Emotions

Share to Exploratory Behavior

Share to Hindlimb Suspension

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin

Share to Tritium

Source

Identifiers

PMID: 16542782
DOI: 10.1016/j.neuroscience.2006.01.049

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.PMID 16542782Read ↗

Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter.Semantic proximity Read ↗

Inactivation of 5HT transport in mice: modeling altered 5HT homeostasis implicated in emotional dysfunction, affective disorders, and somatic syndromes.Semantic proximity Read ↗

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.Semantic proximity Read ↗

Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype.Semantic proximity Read ↗

Investigating anxiety and depressive-like phenotypes in genetic mouse models of serotonin depletion.Semantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models.Semantic proximity Read ↗

Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice.Semantic proximity Read ↗

Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks.Semantic proximity Read ↗

Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.Semantic proximity Read ↗

Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.Semantic proximity Read ↗

Mouse model of the human serotonin transporter-linked polymorphic regionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.