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Article

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression.

Biological psychiatry - 15 Nov 2003

Holmes Andrew, Murphy Dennis L, Crawley Jacqueline N

Abstract excerpt

Evidence of a link between genetic variation of the serotonin transporter and depression and anxiety prompted the generation of serotonin transporter knockout mice. Loss of serotonin reuptake function in knock-outs causes reduced clearance of extracellular serotonin and associated alterations in serotonin neuronal firing and receptor function. Behavioral phenotyping function in knock-outs revealed genetic...

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Source

Identifiers

PMID: 14625137
DOI: 10.1016/j.biopsych.2003.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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