Article
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998
Heisler L K, Chu H M, Brennan T J, Danao J A, Bajwa P, Parsons L H, Tecott L H
Abstract excerpt
The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the contribution of serotonin 5-HT1A receptors to the regulation of these processes, we have used gene-targeting technology to generate 5-HT1A receptor-mutant mice. These animals lack functional 5-HT1A receptors as indicated...
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