Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.

doi:10.1073/pnas.95.25.15049

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Article

Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998

Heisler L K, Chu H M, Brennan T J, Danao J A, Bajwa P, Parsons L H, Tecott L H

Abstract excerpt

The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the contribution of serotonin 5-HT1A receptors to the regulation of these processes, we have used gene-targ...

Topics

Animals
Anxiety
Brain
Depression
Gene Targeting
Male
Mice
Mice, Inbred C57BL
Mutation
Receptors, Serotonin

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