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Article

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.

Molecular biology of the cell - 1 Feb 2008

Froget Benoît, Blaisonneau Joël, Lambert Sarah, Baldacci Giuseppe

Abstract excerpt

During replication arrest, the DNA replication checkpoint plays a crucial role in the stabilization of the replisome at stalled forks, thus preventing the collapse of active forks and the formation of aberrant DNA structures. How this checkpoint acts to preserve the integrity of replication structures at stalled fork is poorly understood. In Schizosaccharomyces pombe, the DNA replication checkpoint kinase Cds1...

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Identifiers

PMID: 18032583
DOI: 10.1091/mbc.e07-07-0728
PMCID: PMC2230577

Genes

BLM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint.PMID 18032583Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks.Semantic proximity Read ↗

Active Replication Checkpoint Drives Genome Instability in Fission Yeast mcm4 Mutant.Semantic proximity Read ↗

Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.Semantic proximity Read ↗

Regulation of DNA replication machinery by Mrc1 in fission yeast.Semantic proximity Read ↗

Mus81 is essential for sister chromatid recombination at broken replication forks.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.Semantic proximity Read ↗

Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Semantic proximity Read ↗

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Semantic proximity Read ↗

FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.Semantic proximity Read ↗

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