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Article

A novel chk1-dependent G1/M checkpoint in fission yeast.

Journal of cell science - 15 Sept 2002

Synnes Marianne, Nilssen Esben A, Boye Erik, Grallert Beáta

Abstract excerpt

Fission yeast cells with a temperature-sensitive Orp1 protein, a component of the origin recognition complex, cannot perform DNA replication at the restrictive temperature. Seventy percent of orp1-4 cells arrest with a 1C DNA content, whereas 30% proceed to mitosis ('cut'). The arrest depends upon the checkpoint Rad proteins and, surprisingly, the Chk1 protein, which is thought to act only from late S phase. The...

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Identifiers

PMID: 12186947
DOI: 10.1242/jcs.00004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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