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Article

Checkpoint-independent scaling of the Saccharomyces cerevisiae DNA replication program.

BMC biology - 7 Oct 2014

Gispan Ariel, Carmi Miri, Barkai Naama

Abstract excerpt

BACKGROUND: In budding yeast, perturbations that prolong S phase lead to a proportionate delay in the activation times of most origins. The DNA replication checkpoint was implicated in this scaling phenotype, as an intact checkpoint was shown to be required for the delayed activation of late origins in response to hydroxyurea treatment. In support of that, scaling is lost in cells deleted of mrc1, a mediator of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25288172
DOI: 10.1186/s12915-014-0079-z
PMCID: PMC4218987

Genes

MRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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