Article
Role of fission yeast primase catalytic subunit in the replication checkpoint.
Molecular biology of the cell - 1 Jan 2001
Griffiths D J, Liu V F, Nurse P, Wang T S
Abstract excerpt
To investigate the cell cycle checkpoint response to aberrant S phase-initiation, we analyzed mutations of the two DNA primase subunit genes of Schizosaccharomyces pombe, spp1(+) and spp2(+) (S. pombe primase 1 and 2). spp1(+) encodes the catalytic subunit that synthesizes the RNA primer, which is then utilized by Polalpha to synthesize the initiation DNA. Here, we reported the isolation of the fission yeast...
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