Article
Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria.
The Journal of infectious diseases - 1 Sept 2008
Leoratti Fabiana M S, Farias Lilian, Alves Fabiana P, Suarez-Mútis Martha C, Coura José R, Kalil Jorge, Camargo Erney P, Moraes Sandra L, Ramasawmy Rajendranath
Abstract excerpt
BACKGROUND: Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated with susceptibility to infectious diseases. METHODS: We genotyped single nucleotide polymorphisms (SNPs) of the genes...
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