Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jan 2006

Mockenhaupt Frank P, Cramer Jakob P, Hamann Lutz, Stegemann Miriam S, Eckert Jana, Oh Na-Ri, Otchwemah Rowland N, Dietz Ekkehart, Ehrhardt Stephan, Schröder Nicolas W J, Bienzle Ulrich, Schumann Ralf R

Abstract excerpt

Genetic host factors play a substantial role in susceptibility to and severity of malaria, which continues to cause at least one million deaths per year. Recently, members of the toll-like receptor (TLR) family have been shown to be involved in recognition of the etiologic organism Plasmodium falciparum: The glycosylphosphatidylinositol anchor induces signaling in host cells via TLR-2 and -4, whereas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ghana
Share to Malaria, Falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Mutation, Missense

Share to Odds Ratio

Share to Toll-Like Receptor 2

Share to Toll-Like Receptor 4

Share to Toll-Like Receptor 9

Source

Open in PubMed Open full text

Identifiers

PMID: 16371473
DOI: 10.1073/pnas.0506803102
PMCID: PMC1324982

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.PMID 16371473Read ↗

Toll-like receptor (TLR) polymorphisms in African children: common TLR-4 variants predispose to severe malaria.Semantic proximity Read ↗

Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian children.Semantic proximity Read ↗

Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies.Semantic proximity Read ↗

Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.Semantic proximity Read ↗

Toll-like receptor 9 (TLR9) polymorphism associated with symptomatic malaria: a cohort study.Semantic proximity Read ↗

Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.Semantic proximity Read ↗

Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in LagosSemantic proximity Read ↗

The toll-like receptor 1 variant S248N influences placental malaria.Semantic proximity Read ↗

A Toll-like receptor-1 variant and its characteristic cellular phenotype is associated with severe malaria in Papua New Guinean children.Semantic proximity Read ↗

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana.Semantic proximity Read ↗

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.Semantic proximity Read ↗

TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.