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Article

Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children.

Malaria journal - 7 Jun 2023

Ariff Amir, Song Yong, Aguilar Ruth, Nhabomba Augusto, Manaca Maria Nelia, Khoo Siew-Kim, Wiertsema Selma, Bassat Quique, Barbosa Arnoldo, Quintó Llorenç, Laing Ingrid A, Guinovart Caterina, Alonso Pedro L, Dobaño Carlota, Le Souëf Peter, Zhang Guicheng

Abstract excerpt

BACKGROUND: Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. METHODS: One hundred and eighty-seven single nucleotide polymorphisms (SNPs) in 37 candidate genes were genotyped and investigated for associations with clinical malaria in a longitudinal cohort of 349 infants from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37287037
DOI: 10.1186/s12936-023-04549-8
PMCID: PMC10245343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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