Article
Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil.
PloS one - 1 Jan 2017
Costa Allyson Guimarães, Ramasawmy Rajendranath, Ibiapina Hiochelson Najibe Santos, Sampaio Vanderson Souza, Xábregas Lilyane Amorim, Brasil Larissa Wanderley, Tarragô Andréa Monteiro, Almeida Anne Cristine Gomes, Kuehn Andrea, Vitor-Silva Sheila, Melo Gisely Cardoso, Siqueira André Machado, Monteiro Wuelton Marcelo, Lacerda Marcus Vinicius Guimarães, Malheiro Adriana
Abstract excerpt
BACKGROUND: Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated molecular patterns (PAMPs) and receptors of innate immunity, such as toll-like receptors (TLRs). The triggering of the signaling...
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