Article
Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.
Science (New York, N.Y.) - 25 Jul 2008
Rolef Ben-Shahar Tom, Heeger Sebastian, Lehane Chris, East Philip, Flynn Helen, Skehel Mark, Uhlmann Frank
Abstract excerpt
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3...
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