Article
Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.
Molecular cell - 27 Mar 2009
Rowland Benjamin D, Roig Maurici B, Nishino Tatsuya, Kurze Alexander, Uluocak Pelin, Mishra Ajay, Beckouët Frédéric, Underwood Philippa, Metson Jean, Imre Richard, Mechtler Karl, Katis Vittorio L, Nasmyth Kim
Abstract excerpt
Cohesin's Smc1, Smc3, and Scc1 subunits form a tripartite ring that entraps sister DNAs. Scc3, Pds5, and Rad61 (Wapl) are regulatory subunits that control this process. We describe here smc3, scc3, pds5, and rad61 mutations that permit yeast cell proliferation and entrapment of sister DNAs by cohesin rings in the absence of Eco1, an acetyl transferase normally essential for establishing sister chromatid cohesion....
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