Article

The acetyltransferase Eco1 elicits cohesin dimerization during S phase

2020-02-07

Abstract excerpt

Sister chromatid cohesion is established by Eco1 in S phase. Nevertheless, the exact consequence of Eco1-catalyzed acetylation is unknown, and the cohesive state remains highly controversial. Here we show that self-interactions of cohesin subunits Scc1/Rad21 and Scc3 occur in a DNA replication-coupled manner in both yeast and human. Through cross-linking mass spectrometry and VivosX analysis of purified cohesin, w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ab055c2-473d-5cb9-bb0d-40e8770a074a
DOI: 10.1101/2020.02.07.938530

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The acetyltransferase Eco1 elicits cohesin dimerization during S phaseDOI 10.1101/2020.02.07.938530Read

Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.Semantic proximity Read

Controlling mechanism of the Scc2-cohesin interaction to restrict peri-centromeric DNA loop expansion and facilitate mitotic chromosome segregationSemantic proximity Read

Region-specific generation and retention of acetylated cohesin shape the genome-wide pattern of sister chromatid cohesionSemantic proximity Read

Non-Redundant Roles in Sister Chromatid Cohesion of the DNA Helicase DDX11 and the SMC3 Acetyl Transferases ESCO1/2Semantic proximity Read

Pds5 promotes and protects cohesin acetylation.Semantic proximity Read

Functional control of Eco1 through the MCM complex in sister chromatid cohesion.Semantic proximity Read

PCNA promotes context-specific sister chromatid cohesion establishment separate from that of chromatin condensation.Semantic proximity Read

Closing the cohesin ring: structure and function of its Smc3-kleisin interface.Semantic proximity Read

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).Semantic proximity Read

Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction.Semantic proximity Read

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.Semantic proximity Read

G1-Cyclin2 (Cln2) promotes chromosome hypercondensation in <i>eco1/ctf7 rad61</i> null cells during hyperthermic stress in <i>Saccharomyces cerevisiae</i>Semantic proximity Read