Article
Pds5 promotes and protects cohesin acetylation.
Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013
Chan Kok-Lung, Gligoris Thomas, Upcher William, Kato Yuki, Shirahige Katsuhiko, Nasmyth Kim, Beckouët Frédéric
Abstract excerpt
Cohesin's Smc1 and Smc3 subunits form V-shaped heterodimers, the nucleotide binding domains (NBDs) of which bind the C- and N-terminal domains, respectively, of the α-kleisin subunit, forming a large tripartite ring within in which sister DNAs are entrapped, and thereby held together (sister chromatid cohesion). During replication, establishment of stable cohesion is dependent on Eco1-mediated acetylation of...
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