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Article

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase.

Molecular cell - 6 May 2011

Lyons Nicholas A, Morgan David O

Abstract excerpt

Accurate genome segregation depends on cohesion mechanisms that link duplicated sister chromatids, thereby allowing their tension-dependent biorientation in metaphase. In Saccharomyces cerevisiae, cohesion is established during DNA replication when Eco1 acetylates the cohesin subunit Smc3. Cohesion establishment is restricted to S phase of the cell cycle, but the molecular basis of this regulation is unknown....

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Identifiers

PMID: 21549314
DOI: 10.1016/j.molcel.2011.03.023
PMCID: PMC3095509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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