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Article

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).

Science (New York, N.Y.) - 13 Jul 2007

Unal Elçin, Heidinger-Pauli Jill M, Koshland Douglas

Abstract excerpt

Faithful chromosome segregation and repair of DNA double-strand breaks (DSBs) require cohesin, the protein complex that mediates sister-chromatid cohesion. Cohesion between sister chromatids is thought to be generated only during ongoing DNA replication by an obligate coupling between cohesion establishment factors such as Eco1 (Ctf7) and the replisome. Using budding yeast, we challenge this model by showing that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17626885
DOI: 10.1126/science.1140637

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).PMID 17626885Read ↗

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Functional control of Eco1 through the MCM complex in sister chromatid cohesion.Semantic proximity Read ↗

The cohesin acetyltransferase Eco1 coordinates rDNA replication and transcription.Semantic proximity Read ↗

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